Technical literature
Technical papers archive
Friday 1st September 2006
Effects of steam pasteurisation on Salmonella Typhimurium DT104 and Escherichia coli O157:H7 surface inoculated onto beef, pork and chicken
The following paper cites the use of aCOLyte colony counter.
Monday 29th May 2006
Evaluation of adenyl cyclase toxin constructs from Bordetella pertussis as candidate vaccine components in an in vitro model of complement-dependent intraphagocytic killing
The following paper cites the use of ProtoCOL colony counter.
Friday 10th February 2006
Host Genetics of Bordetella pertussis Infection in Mice: Significance of Toll-Like Receptor 4 in Genetic Susceptibility and Pathobiology
The following article cites the use of ProtoCOL.
Tuesday 1st November 2005
Identification of a dithiazoline inhibitor of Escherichia coli L,D-carboxypeptidase A
The following paper cites the use of ProtoCOL
Friday 1st July 2005
Comparative in vitro activities of daptomycin, linezolid, and quinupristin/dalfopristin against Gram-positive bacterial isolates from a large cancer center
The following paper cites the use of aCOLyte colony counter.
Tuesday 3rd May 2005
Simplified method to automatically count bacterial colony forming unit (Opsonophagocytosis assay, Bacterial colony counting)
Bacterial colony counting is a significant technical hurdle for vaccine studies as well as various microbiological studies. We now show that an automated colony counter can process images obtained with a digital camera or document scanner and that any laboratory can efficiently have bacterial colonies enumerated by sending the images to a laboratory with a colony counter via internet. (This Research Paper appeared in the Journal of Immunological Methods 302 (2005) 99 - 102).
Wednesday 2nd March 2005
Modulation of gene expression by promoter mutants of the λ cI857/pRM/pR system
The following paper cites the use of ProtoCOL colony counter.
Tuesday 1st February 2005
Clinical isolates of Staphylococcus aureus from 1987 and 1989 demonstrating heterogeneous resistance to vancomycin and teicoplanin
The following paper cites the use of ProtoCOL colony counter.
Monday 1st November 2004
Automating color colony counting
To check the safety of foods, microbiologists routinely liquefy and plate samples onto agar plates. They then examine the food for potentially pathogenic bacteria such as Salmonella, E.coli 0157, Bacillus cereus, and Listeria monocytogenes, as well as anaerobes such as Campylobacter. On the basis of the level of potentially harmful bacteria in the sample, decisions are made as to whether to market the product.
Wednesday 1st September 2004
Automated colony counting proves accurate
Producing new anti-microbial therapies and vaccines to treat biological terrorism threats such as anthrax and smallpox has become a priority. Since colony counts provide the data on which the efficacy of this type of treatment is based, it is essential to obtain accurate counts in the shortest possible time.
Sunday 1st August 2004
Colonies are clearly visible - new assay allows automated colony counting
Evaluations of pneumococcal vaccines using the OPKA (opsonophagocytic-killing assay) require the determination of antibody responses, which is commonly performed by enumerating surviving bacterial colonies.
Monday 1st December 2003
A novel method for automating zone measurement of SRD assays
Single radial immunodiffusion (SRD) is a simple yet powerful technique that is routinely used in many clinical laboratories for a wide variety of analyses. Despite its simplicity, the technique as currently practiced suffers from a major drawback due to the fact that in general, the measurement of the reaction zones generated by the assay is performed manually. This is a task that is time-consuming and error-prone. To overcome these problems, a novel method of automating inhibition zone measurement has been developed. The new system has been extensively tested and compared with the standard, manual method. We report here the performance of the new method in the assay of the potency of influenza vaccines.
Monday 1st September 2003
Microbiological quality control procedures improved through use of modern image analysis
One of the main functions of microbiology laboratories in modern pharmaceutical companies is to carry out routine quality control testing. This involves testing various types of samples for the presence of contaminating bacteria. Although the initial screening tests are performed using relatively simple culture plates, the fact that large numbers of such plates have to be screened means that accurate archiving and transmission of the results can be a challenge. Modern image handling and archiving systems can dramatically improve the reliability of microbiology QC systems and ensure speedy transmission of potentially vital data to the appropriate site. The case study presented in this article describes how AstraZeneca have successfully incorporated the use of image handling systems into their microbiology QC procedures.
Monday 31st March 2003
Efficiency of a Pneumococcal Opsonophagocytic Killing Assay Improved by Multiplexing and by Coloring Colonies
This article cites the use of ProtoCOL.
Saturday 1st September 2001
Effective object recognition for automated counting of colonies in Petri dishes (automated colony counting)
The following paper cites the use of Synbiosis products.
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